THERAPY DOSSIER · th-a1adcaf94c17

Embryonic (fetal) rat nervous tissue transplant

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01898390 ↗NAcompleted

Neural Allo-Transplantation With Fetal Ventral Mesencephalic Tissue in Patients With Parkinson's Disease

Parkinson's Disease

Enrolment: 13 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 3235824 ↗1988Mixed findings

Changes of DNA synthesis in brain cortical cells after transplantation of embryonic nervous tissue into the brain of rats after hypoxia.

RatOtherInbred strain (not further specified)FemaleIntracerebral transplantationAfter hypoxic insult

Model: Acute hypoxic hypoxia causing mass dystrophy of cortical neurons

Transplantation stimulated DNA synthesis in non-neuronal cells (glia, macrophages, endothelial cells), more so in the operated hemisphere and more in intact than in hypoxia-exposed rats. DNA synthesis was essentially absent in neurons apart from occasional cells near the wound canal and transplant.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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