Interleukin-22 ameliorated acetaminophen-induced kidney injury by inhibiting mitochondrial dysfunction and inflammatory responses.

Interleukin-22 ameliorated acetaminophen-induced kidney injury by inhibiting mitochondrial dysfunction and inflammatory responses.

Model: Acetaminophen (paracetamol) overdose-induced acute kidney injury, with parallel in vitro renal tubular epithelial cell studies

IL-22 reduced reactive oxygen species accumulation and mitochondrial dysfunction and lowered tubular epithelial cell death in vitro and in vivo. NLRP3 inflammasome activation, mature IL-1beta release and serum IL-18, TNF-alpha, IL-6 and IL-1beta were all reduced.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.