Efficacy and Safety of ILV-094 (anti-IL-22 antibody) Administered Subcutaneously in Rheumatoid Arthritis
Rheumatoid Arthritis
Enrolment: 195 · Results not recorded
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Biologic
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Rheumatoid Arthritis
Enrolment: 195 · Results not recorded
Type 2 Diabetes Mellitus · Obesity and Overweight
Enrolment: 90 · Results not recorded
Alcohol-associated Hepatitis
Enrolment: 216 · Results not recorded
Acute Graft vs Host Disease
Enrolment: 30 · Results not recorded
Healthy
Enrolment: 76 · Results not recorded
Refractory Malignant Solid Tumors
Enrolment: 6 · Results not recorded
Pulmonary Disease, Chronic Obstructive · Bacterial Infections
Enrolment: 23 · Results not recorded
Inflammatory Bowel Disease
Enrolment: 52 · Results not recorded
Vitiligo
Enrolment: 60 · Results not recorded
Atopic Dermatitis
Enrolment: 45 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Acetaminophen (paracetamol) overdose-induced acute kidney injury, with parallel in vitro renal tubular epithelial cell studies
IL-22 reduced reactive oxygen species accumulation and mitochondrial dysfunction and lowered tubular epithelial cell death in vitro and in vivo. NLRP3 inflammasome activation, mature IL-1beta release and serum IL-18, TNF-alpha, IL-6 and IL-1beta were all reduced.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Ethanol gavage (blood ethanol approximately 100 mg/dL) followed four hours later by a scald burn covering approximately 12.5% of total body surface area, under ketamine 80 mg/kg and xylazine 1.2 mg/kg anaesthesia
IL-22 restored crypt epithelial proliferation, raised antimicrobial peptide transcripts, eliminated the Enterobacteriaceae expansion and partially reduced hepatic and pulmonary inflammatory markers; protection was completely lost in intestinal epithelial STAT3 knockout mice.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: L-arginine induced severe acute pancreatitis with associated lung injury
Recombinant IL-22 significantly reduced serum amylase and lung myeloperoxidase activity relative to the severe acute pancreatitis group and improved pancreatic and lung histological injury. It increased Bcl-2, Bcl-xL and IL-22RA1 mRNA expression and raised the phosphorylated STAT3 to STAT3 ratio co…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Acute ethanol intoxication by gavage followed by a full-thickness scald burn of approximately 12.5% total body surface area
IL-22 treatment normalised intestinal Reg3β and Reg3γ expression and attenuated the rise in intestinal permeability after combined ethanol and burn injury, and reduced bacterial load in about half of treated mice.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.78. Machine-extracted fields require source verification.