Indomethacin attenuates mechanical allodynia during the organization but not the maintenance of the peripheral neuropathic pain induced by nervus ischiadicus chronic constriction injury.

Indomethacin attenuates mechanical allodynia during the organization but not the maintenance of the peripheral neuropathic pain induced by nervus ischiadicus chronic constriction injury.

Model: Chronic constriction injury of the right nervus ischiadicus, adapted from Bennett and Xie, with one loose 4.0 chromic gut ligature placed about 7 mm proximal to the trifurcation via blunt dissection through biceps femoris; anaesthesia ketamine 92 mg/kg plus xylazine 9.2 mg/kg

Indomethacin attenuated mechanical allodynia on days 1, 2 and 4 after chronic constriction injury (P<0.05 at 15 and 30 min post-injection) but had no effect at days 7, 14, 21 or 28. Contralateral paw withdrawal thresholds were unchanged.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.