Sequential Wnt Agonist Then Antagonist Treatment Accelerates Tissue Repair and Minimizes Fibrosis.
Model: Renal ischaemia-reperfusion injury with ischaemia duration varied as mild (5 min), moderate (10, 15 and 20 min) and severe (30 min), with 30 days recovery; preconditioning arm used a 10 min ischaemia-reperfusion injury, 30 days recovery, then a second injury of 10 to 30 min; therapeutic validation used 30 min ischaemia
ICG-001 alone or combined with Wnt1 pretreatment markedly reduced fibrosis, whereas Wnt1 pretreatment alone increased fibrosis severity and extracellular matrix deposition; Wnt1 alone or in combination improved survival after 30 min ischaemia. Ischaemic preconditioning reduced the risk of death but…
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