THERAPY DOSSIER · th-200355a1e4ff

Wnt1 (Wnt agonist, delivered as HA-tagged Wnt1 gene) followed by ICG-001 (Wnt antagonist)

Drug · Sequential Wnt1 agonist gene delivery then ICG-001, a CBP/beta-catenin (Wnt pathway) antagonist; ChEMBL returned only the ICG-001 enantiomer PRI-724.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Sequential Wnt1 agonist gene delivery then ICG-001, a CBP/beta-catenin (Wnt pathway) antagonist; ChEMBL returned only the ICG-001 enantiomer PRI-724.
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02413853 ↗PHASE2withdrawn

PRI-724 (CBP/beta-catenin Antagonist) With mFOLFOX6/Bevacizumab in Metastatic Colorectal Cancer

Colorectal Adenocarcinoma

Enrolment: 0 · Results not recorded

NCT04688034 ↗PHASE1completed

CBP/Beta-catenin Inhibitor OP-724 (ICG-001 analog) in Liver Cirrhosis (HIV/HCV)

Liver Cirrhosis

Enrolment: 5 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32339988 ↗2020Mixed findings

Sequential Wnt Agonist Then Antagonist Treatment Accelerates Tissue Repair and Minimizes Fibrosis.

MouseIschaemia-reperfusionRenaln = Partial only: four of seven mice survived each moderate isc…Wnt1 by hydrodynamic gene delivery (tail vein hydrodynamic injection); ICG-001 route not stated in the main textSingle Wnt1 pretreatment before ischaemia-reperfusion injury; ICG-001 given eve…

Model: Renal ischaemia-reperfusion injury with ischaemia duration varied as mild (5 min), moderate (10, 15 and 20 min) and severe (30 min), with 30 days recovery; preconditioning arm used a 10 min ischaemia-reperfusion injury, 30 days recovery, then a second injury of 10 to 30 min; therapeutic validation used 30 min ischaemia

ICG-001 alone or combined with Wnt1 pretreatment markedly reduced fibrosis, whereas Wnt1 pretreatment alone increased fibrosis severity and extracellular matrix deposition; Wnt1 alone or in combination improved survival after 30 min ischaemia. Ischaemic preconditioning reduced the risk of death but…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.78. Machine-extracted fields require source verification.

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