Reperfusion combined with intraarterial administration of resveratrol-loaded nanoparticles improved cerebral ischemia-reperfusion injury in rats.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMaleIntra-arterial infusionGiven in conjunction with reperfusion
Model: Transient middle cerebral artery occlusion with reperfusion, modelling large artery occlusion stroke treated by endovascular thrombectomy
Intra-arterial resveratrol-loaded nanoparticles gave significant protection against cerebral ischaemia-reperfusion injury, attenuating oxidative stress and brain oedema. Neuronal apoptosis was reduced and neurogenesis increased with higher brain-derived neurotrophic factor expression.
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