Use of Resveratrol to Decrease Secondary Brain Injury Following Sports-Related Concussions: a Double-Blind, Placebo-Controlled Study
Sports Concussion
Enrolment: 12 · Results not recorded
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Nutraceutical
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Sports Concussion
Enrolment: 12 · Results not recorded
Halitosis · Periodontal Disease
Enrolment: 54 · Results not recorded
Non Alcoholic Fatty Liver
Enrolment: 50 · Results not recorded
Mild Cognitive Impairment
Enrolment: 330 · Results not recorded
Amyotrophic Lateral Sclerosis
Enrolment: 90 · Results not recorded
Spastic Paraplegia, Hereditary
Enrolment: 12 · Results not recorded
Friedreich Ataxia
Enrolment: 27 · Results not recorded
Memory
Enrolment: 32 · Results not recorded
Inflammation Biomarkers · Cardiometabolic Health Indicators
Enrolment: 75 · Results not recorded
Healthy
Enrolment: 42 · Results not recorded
Aging · Infertility
Enrolment: 88 · Results not recorded
Healthy
Enrolment: 15 · Results not recorded
Infertility, Female
Enrolment: 100 · Results not recorded
Cognitive Function and Mood · Cerebral Blood Flow · Systemic Inflammation · Gut Microbiota · Overweight and Obesity
Enrolment: 110 · Results not recorded
Obesity · Insulin Resistance · Metabolic Syndrome
Enrolment: 28 · Results not recorded
Impaired Glucose Tolerance
Enrolment: 36 · Results not recorded
Polycystic Ovary Syndrome (PCOS)
Enrolment: 40 · Results not recorded
Type 2 Diabetes Mellitus
Enrolment: 20 · Results not recorded
19 studies reported at therapy level; 25 evidence entries itemised.
Model: Spinal cord injury by clip compression at T4-5
Resveratrol, quercetin and their combination significantly increased total antioxidant capacity and paraoxonase activity compared with trauma alone, with no significant difference between resveratrol and quercetin. Polymorphonuclear leukocyte infiltration was reduced in solvent, resveratrol, querce…
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Model: Single abdominal radiation treatment at 17.5 Gy, acute inflammation assessed at day 10
All experimental diets reduced triglyceride, monocytes, proinflammatory cytokines and urinary 8-OHdG and increased platelet counts. High-protein diets lowered LDL cholesterol and total cholesterol and restored white blood cell counts, and the high-protein and resveratrol diets lowered regulatory T…
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Model: Transient middle cerebral artery occlusion with reperfusion, modelling large artery occlusion stroke treated by endovascular thrombectomy
Intra-arterial resveratrol-loaded nanoparticles gave significant protection against cerebral ischaemia-reperfusion injury, attenuating oxidative stress and brain oedema. Neuronal apoptosis was reduced and neurogenesis increased with higher brain-derived neurotrophic factor expression.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Blunt hepatic trauma
Resveratrol lowered serum AST, ALT and LDH relative to untreated trauma and reduced inflammation scores (1.42 plus or minus 0.53 versus 2.42 plus or minus 0.53, p = 0.001), with the highest Ki-67, Bcl-2 and Bax scores in the treated group.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Isoproterenol induced myocardial injury, isoproterenol 85 mg/kg
Resveratrol at 50 mg/kg improved cardiac injury and stress biomarkers and reduced iNOS, microRNA-34a and p38 MAPK compared with isoproterenol alone.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Doxorubicin-induced cardiotoxicity
Resveratrol combined with doxorubicin attenuated cardiotoxicity and up-regulated VEGF-B, and small interfering RNA knockdown of VEGF-B abolished the protection.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Blunt chest trauma-induced acute lung injury; method of trauma induction not specified in the abstract
Resveratrol increased superoxide dismutase activity and the authors concluded it exerted antioxidant properties in blunt chest trauma-induced lung injury. Serum endocan rose in all trauma and resveratrol groups and was not correlated with the inflammatory response, so the authors did not recommend…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Doxorubicin-induced skeletal muscle myotoxicity in young and aged senescence-accelerated mice
Resveratrol attenuated doxorubicin-induced increases in apoptotic and catabolic markers in aged skeletal muscle, and these benefits were abolished by the SIRT1 inhibitors sirtinol or EX527. Insulin signalling markers were unaffected by either doxorubicin or resveratrol.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Acute doxorubicin hydrochloride-induced cardiotoxicity in healthy mice
The 10:10:1 resveratrol:quercetin:doxorubicin combination was synergistic in ovarian cancer cells and antagonistic in cardiomyocytes, scavenging reactive oxygen species and reducing caspase 3/7 activity only in cardiomyocytes. In mice, co-administration of the micelles with acute doxorubicin confer…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Full-thickness scald burn over 30% total body surface area (92 degrees C water, 18 s) with remote acute lung injury
Resveratrol upregulated SIRT1 and reduced burn-induced lung histopathology score, pro-inflammatory cytokine expression, cleaved caspase-3 and BALF protein leak; SIRT1 knockdown had the opposite effect, implicating p38 MAPK signalling.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Weight-drop impact spinal cord injury at the T10 vertebral level with remote lung inflammatory damage
Resveratrol alleviated spinal cord injury-induced pulmonary oedema, reduced neutrophil infiltration and inflammatory mediator production, upregulated SIRT1 and suppressed NF-kB activity in lung tissue.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Pulmonary contusion followed by second-hit challenge with caecal ligation and puncture or intratracheal lipopolysaccharide
Pulmonary contusion reduced lung SIRT1 protein, messenger RNA and enzyme activity and primed mice for exaggerated responses to infection or lipopolysaccharide. Resveratrol treatment decreased polymorphonuclear leukocyte influx into bronchoalveolar lavage after intratracheal lipopolysaccharide (50 u…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Closed-head controlled cortical impact mild traumatic brain injury with impact on the sagittal suture midway between bregma and lambda, depth 2.0 mm, velocity 4 m/s and dwell time 100 milliseconds
Resveratrol reduced Iba1 microglial activation in the cerebral cortex, corpus callosum and dentate gyrus and lowered hippocampal IL-6 and IL-12 at 72 hours after mild traumatic brain injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: 4 cm midline laparotomy incision
Resveratrol significantly increased fascial tensile strength and hydroxyproline levels at day 14 and raised acute inflammation, collagen deposition and neovascularisation scores at days 7 and 14, with higher granulation tissue and fibroblast maturation scores at day 14.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Total body irradiation causing acute bone marrow syndrome and long-term haematopoietic stem cell injury
Resveratrol pretreatment protected mice from acute bone marrow syndrome and lethality and ameliorated long-term bone marrow injury by reducing haematopoietic stem cell reactive oxygen species and senescence, an effect attenuated by the Sirt1 inhibitor Ex527.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: acute ovarian toxicity induced by total body irradiation
Both resveratrol doses gave significantly higher total follicle counts than the irradiated control group (P < 0.01), with the low dose preserving more primary follicles than the high dose. Glutathione peroxidase and catalase activities were significantly raised in resveratrol-treated animals. Fibro…
Extraction: extract · Supplied extraction confidence: 0.78. Machine-extracted fields require source verification.
Model: Staphylococcal enterotoxin B (SEB) induced acute lung inflammation, 50 microg per mouse administered intranasally
Pretreatment and post-treatment with resveratrol significantly reduced SEB-induced pulmonary vascular permeability and inflammation, reduced lung infiltrating cells and attenuated the cytokine storm. This correlated with increased caspase-8 dependent apoptosis in SEB activated T cells, upregulation…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: plantar incision model of post-surgical pain, a 5 mm longitudinal incision through skin, fascia and muscle of the plantar hindpaw; also an intraplantar IL-6 hyperalgesic priming model
Local resveratrol dose-dependently reduced incision-induced mechanical allodynia and blocked the development of persistent nociceptive sensitisation, while activating AMPK and suppressing ERK and mTOR signalling in sensory neurons.
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Model: Postnatal day 7 hypoxia-ischaemia in a context of moderate maternal alcohol exposure (0.5 g/kg/day in drinking water during pregnancy and lactation)
Moderate maternal alcohol exposure did not increase MRI lesion volume but worsened motor impairment. Resveratrol did not reverse the deleterious effects, whereas piceatannol restored all sensorimotor and cognitive functions, at a dose corresponding to about one passion fruit per day for a pregnant…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
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