L. Extract Does Not Induce Fibroblast to Myofibroblast Conversion but Increases Extracellular Matrix Production In Vitro Leading to Increased Wound Tensile Strength in Rats.
RatWoundSprague-DawleyMalen = 56 rats in total, four groups of 14; half of each group kil…Topical, applied to the wound surface by eye dropper1% (1 g lyophilised extract in 100 mL sterile water, HCE-1)…From wounding onwards, during the first three days after wounding
Model: One 4 cm full-thickness skin incision closed with an intradermal running suture and one round 1 cm diameter full-thickness excision on the dorsum, under ketamine 33 mg/kg and xylazine 11 mg/kg intramuscular with tramadol 5 mg/kg; wounds left undressed
At day 7 only the 0.1% extract raised tensile strength (16.4 plus or minus 3.8 versus 5.9 plus or minus 2.5 g/mm untreated control, 8.5 plus or minus 1.7 aqueous control and 8.9 plus or minus 2.5 for 1%). At day 21 both concentrations significantly raised tensile strength (0.1%: 85.9 plus or minus…
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.