THERAPY DOSSIER · th-231b7d841a02

Horse chestnut (Aesculus hippocastanum) aqueous extract, containing 14.43% escin isomers

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 7

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02346058 ↗PHASE4completed

Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency or Varicose Vein with Superficial Vein Thrombophlebitis

Chronic Venous Insufficiency · Varicose Vein · Superficial Vein Thrombophlebitis

Enrolment: 53 · Results not recorded

NCT06579482 ↗PHASE4completed

Non-inferiority of Aesculus Hippocastanum Combination vs Diosmin/Hesperidin in Chronic Venous Insufficiency

Chronic Venous Insufficiency

Enrolment: 120 · Results not recorded

NCT04035317 ↗PHASE2withdrawn

Effect of Aesculus Hippocastanum L. on Fontan Circulation - a Randomized Clinical Trial

Univentricular Heart

Enrolment: 0 · Results not recorded

NCT02483962 ↗PHASE2completed

Efficacy of Red Vine Leaf Extract, Butcher's Broom, Horse Chestnut and Vitamin B6 in Chronic Venous Insufficiency

Venous Insufficiency

Enrolment: 40 · Results not recorded

NCT00213928 ↗PHASE2completed

Single-blind Randomized Trial of Horse Chestnut Seed Extract for Lymphedema of the Arm in Breast Cancer Survivors

Lymphedema of Arm

Enrolment: 56 · Results not recorded

NCT06748014 ↗EARLY_PHASE1enrolling by invitation

Efficacy of Aescin With MPFF in Control of Bleeding and Prevention of Recurrence of Acute Internal Hemorrhoids (Pilot)

Hemorrhoid

Enrolment: 120 · Results not recorded

NCT06363513 ↗NAunknown

Efficacy of Aescin With Micronized Purified Flavonoid Fraction in Early Control of Bleeding From Acute Internal Hemorrhoids

Anorectal Disorder

Enrolment: 60 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32331226 ↗2020Reported benefit

L. Extract Does Not Induce Fibroblast to Myofibroblast Conversion but Increases Extracellular Matrix Production In Vitro Leading to Increased Wound Tensile Strength in Rats.

RatWoundSprague-DawleyMalen = 56 rats in total, four groups of 14; half of each group kil…Topical, applied to the wound surface by eye dropper1% (1 g lyophilised extract in 100 mL sterile water, HCE-1)…From wounding onwards, during the first three days after wounding

Model: One 4 cm full-thickness skin incision closed with an intradermal running suture and one round 1 cm diameter full-thickness excision on the dorsum, under ketamine 33 mg/kg and xylazine 11 mg/kg intramuscular with tramadol 5 mg/kg; wounds left undressed

At day 7 only the 0.1% extract raised tensile strength (16.4 plus or minus 3.8 versus 5.9 plus or minus 2.5 g/mm untreated control, 8.5 plus or minus 1.7 aqueous control and 8.9 plus or minus 2.5 for 1%). At day 21 both concentrations significantly raised tensile strength (0.1%: 85.9 plus or minus…

Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.

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