A novel CX3CR1 inhibitor AZD8797 facilitates early recovery of rat acute spinal cord injury by inhibiting inflammation and apoptosis.
RatSpinal cord injuryCompressionSprague-DawleyMalen = 75 rats used, 65 analysed; subset I 25 rats in 5 groups (n=…Intraperitoneal injection80 micrograms/kg, dissolved in DMSOAfter spinal cord injury; exact interval not stated (positive control methylpre…
Model: Clip compression spinal cord injury at T10 using a clamp with 30 g closing pressure applied for 20 seconds after laminectomy
AZD8797 improved locomotor recovery at 10 days after injury to a degree comparable with methylprednisolone. Benefit was accompanied by reduced apoptosis and necrosis and lower serum TNF-alpha, IL-6 and IL-1beta.
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