THERAPY DOSSIER · th-0eaa41615017

AZD8797

Drug · CX3CR1 (fractalkine receptor) allosteric antagonist (no ChEMBL mechanism record).

Evidence & regulatory context

Mechanism: CX3CR1 (fractalkine receptor) allosteric antagonist (no ChEMBL mechanism record).
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL2349310 ↗
ChEMBL max phase: 2 / 4 (development scale, not regulatory approval)
Synonyms: AZD8797; KAND567; Kand-567
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06087289 ↗PHASE2completed

KANDOVA: KAND567 + carboplatin in recurrent ovarian/fallopian/peritoneal cancer

Epithelial Ovarian Cancer · Fallopian Tube Cancer · Peritoneal Cancer

Enrolment: 18 · Results not recorded

NCT06012565 ↗PHASE2terminated

KAND567 vs placebo in hospitalized COVID-19

Covid19

Enrolment: 35 · Results not recorded

NCT06030375 ↗PHASE1completed

Safety/PK of continuous infusion of KAND567 in healthy subjects

Healthy

Enrolment: 23 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32323731 ↗2020Reported benefit

A novel CX3CR1 inhibitor AZD8797 facilitates early recovery of rat acute spinal cord injury by inhibiting inflammation and apoptosis.

RatSpinal cord injuryCompressionSprague-DawleyMalen = 75 rats used, 65 analysed; subset I 25 rats in 5 groups (n=…Intraperitoneal injection80 micrograms/kg, dissolved in DMSOAfter spinal cord injury; exact interval not stated (positive control methylpre…

Model: Clip compression spinal cord injury at T10 using a clamp with 30 g closing pressure applied for 20 seconds after laminectomy

AZD8797 improved locomotor recovery at 10 days after injury to a degree comparable with methylprednisolone. Benefit was accompanied by reduced apoptosis and necrosis and lower serum TNF-alpha, IL-6 and IL-1beta.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.

Loading the evidence…