Neuroregenerative and protective functions of Leukemia Inhibitory Factor in perinatal hypoxic-ischemic brain injury.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)CD-1 wild type; germline LIF-deficient line backcrossed at least 10 times onto CD-1Both; 16 females and 11 males analysed, no sex differences observedn = 27 animals analysed in total, 16 female and 11 male; immuno…Intranasal10 microlitres total of LIF at 2 micrograms/mL, given as 2…Three days after hypoxia-ischaemia, postnatal day 12
Model: Vannucci model of late preterm hypoxic-ischaemic brain injury: right common carotid artery cauterisation under isoflurane, one hour recovery, then 65 minutes of humidified 10 per cent oxygen at 36 degrees C
Intranasal LIF started 3 days after the insult reduced the extent of brain injury by about 60 per cent, attenuated astrogliosis and microgliosis in striatum, improved subcortical white matter thickness and increased Olig2 positive cells in corpus callosum. Sensorimotor test performance improved at…
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