Phase II study of AZD0171 (anti-LIF monoclonal antibody) with durvalumab and chemotherapy in locally advanced or metastatic solid tumours
Locally Advanced or Metastatic Solid Tumours
Enrolment: 126 · Results not recorded
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Biologic · IL-6-family cytokine signalling through the LIFR (CD118)/gp130 heterodimer and downstream JAK1-STAT3, with secondary MAPK and PI3K activation; in nerve injury it is a retrogradely transported injury signal supporting sensory and motor neuron survival. ChEMBL returned no record for 'leukemia inhibitory factor' (recombinant protein, emfilermin, not in the queried index).
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Locally Advanced or Metastatic Solid Tumours
Enrolment: 126 · Results not recorded
Infertility Implantation Failure
Enrolment: 50 · Results not recorded
Infertility Implantation Failure
Enrolment: 150 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Vannucci model of late preterm hypoxic-ischaemic brain injury: right common carotid artery cauterisation under isoflurane, one hour recovery, then 65 minutes of humidified 10 per cent oxygen at 36 degrees C
Intranasal LIF started 3 days after the insult reduced the extent of brain injury by about 60 per cent, attenuated astrogliosis and microgliosis in striatum, improved subcortical white matter thickness and increased Olig2 positive cells in corpus callosum. Sensorimotor test performance improved at…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.