Expression of Notch and Wnt/beta-catenin signaling pathway in acute phase severe brain injury rats and the effect of exogenous thyroxine on those pathways.
RatTBIWeight-drop / impact-accelerationSprague-Dawleyn = 108 rats in 6 groups, 18 per group; 6 rats per group sacrif…Intragastric administrationLow, moderate and high dose groups; numerical doses not sta…6 hours after severe traumatic brain injury
Model: Severe traumatic brain injury induced by Feeney free-fall weight-drop method
Thyroxine reduced brain pathology and Neurological Severity Score after injury, most clearly at moderate and high doses, and lowered serum GFAP and S100B. Wnt3a, beta-catenin, Notch1 and Hes1 mRNA and Bcl-2 increased while Bax decreased, and thyroxine had no effect in uninjured rats.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.