Fresh frozen plasma attenuates lung injury in a novel model of prolonged hypotensive resuscitation.
MouseHaemorrhage/shockControlledC57BL/6JMalen = n=4 to 8 per groupIntra-arterial via femoral artery cannulaTitrated to a mean arterial pressure of 55 to 60 mmHg; mean…Started immediately after the 90 min shock period
Model: Laparotomy with controlled haemorrhagic shock to a mean arterial pressure of 35 plus or minus 5 mmHg for 90 min, followed by 6 h of prolonged hypotensive resuscitation targeting 55 to 60 mmHg
Fresh frozen plasma reduced lung histological injury score (4.38 plus or minus 2.07 versus 7.5 plus or minus 0.93, p=0.002, comparable to sham), lung myeloperoxidase (p=0.002) and Evans blue permeability (7.30 versus 14.91 micrograms per 100 mg lung, p=0.005), and restored pulmonary syndecan-1 (p<0…
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