Prothrombin Complex Concentrate Versus Fresh Frozen Plasma to Correct Coagulation Disorders in Adult Neurosurgical Patients
Intracranial Hemorrhages
Enrolment: 18 · Results not recorded
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Biologic
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Intracranial Hemorrhages
Enrolment: 18 · Results not recorded
Liver Cirrhosis · Ascites Hepatic
Enrolment: 0 · Results not recorded
Covid19
Enrolment: 420 · Results not recorded
Coagulopathy · Endstage Liver Disease
Enrolment: 43 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Laparotomy with controlled haemorrhagic shock to a mean arterial pressure of 35 plus or minus 5 mmHg for 90 min, followed by 6 h of prolonged hypotensive resuscitation targeting 55 to 60 mmHg
Fresh frozen plasma reduced lung histological injury score (4.38 plus or minus 2.07 versus 7.5 plus or minus 0.93, p=0.002, comparable to sham), lung myeloperoxidase (p=0.002) and Evans blue permeability (7.30 versus 14.91 micrograms per 100 mg lung, p=0.005), and restored pulmonary syndecan-1 (p<0…
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Model: 37.5% arterial haemorrhage producing haemorrhagic shock followed by 3 hours of tourniquet-induced hindlimb ischaemia-reperfusion
Fresh frozen plasma reduced muscle oedema by 13% compared with lactated Ringer's solution (p = 0.02), but pathology scores did not differ between treatment groups. Mortality was 50% in non-resuscitated rats.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Haemorrhagic shock and trauma
FFP and SDP performed similarly, preserving endothelial monolayer integrity in vitro, reducing pulmonary vascular permeability, correcting mean arterial pressure and base excess, and reducing alveolar wall thickening, leukocyte infiltration and endothelial junction breakdown, whereas lactated Ringe…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.