Bone marrow mesenchymal stem cells transplantation alleviates brain injury after intracerebral hemorrhage in mice through the Hippo signaling pathway.
MixedOtherC57BL/6 mice; Sprague-Dawley rat bone marrow donorsMalen = Sham n=45, intracerebral haemorrhage plus PBS n=50, plus BM…Stereotactic intracerebral injection into the ipsilateral lesion areaCell suspension in 2 microlitres phosphate buffered saline…24 h after intracerebral haemorrhage
Model: Collagenase IV induced intracerebral haemorrhage, 0.075 U in 0.4 microlitres phosphate buffered saline stereotactically injected into the right basal ganglia at 0.1 microlitres per minute
BM-MSC transplantation reduced day 3 haematoma volume and improved modified neurological severity and corner test scores at days 7 and 14 (p<0.05), with increased vimentin and EAAT1, reduced ALDH1L1 and reduced phospho-MST1 and phospho-YAP. YAP knockdown abolished the BM-MSC driven astrocyte prolif…
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