THERAPY DOSSIER · th-8af3bc70fa29

Bone marrow mesenchymal stem cells (BM-MSC), passages 2 to 5

Biologic · Bone-marrow mesenchymal stem cells (passages 2-5); cell therapy.

Evidence & regulatory context

Mechanism: Bone-marrow mesenchymal stem cells (passages 2-5); cell therapy.
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02409940 ↗PHASE1unknown

Mesenchymal Stem Cells for Immune Modulation in Living Related Kidney Transplant

Renal Transplant Rejection

Enrolment: 17 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32271159 ↗2020Reported benefit

Bone marrow mesenchymal stem cells transplantation alleviates brain injury after intracerebral hemorrhage in mice through the Hippo signaling pathway.

MixedOtherC57BL/6 mice; Sprague-Dawley rat bone marrow donorsMalen = Sham n=45, intracerebral haemorrhage plus PBS n=50, plus BM…Stereotactic intracerebral injection into the ipsilateral lesion areaCell suspension in 2 microlitres phosphate buffered saline…24 h after intracerebral haemorrhage

Model: Collagenase IV induced intracerebral haemorrhage, 0.075 U in 0.4 microlitres phosphate buffered saline stereotactically injected into the right basal ganglia at 0.1 microlitres per minute

BM-MSC transplantation reduced day 3 haematoma volume and improved modified neurological severity and corner test scores at days 7 and 14 (p<0.05), with increased vimentin and EAAT1, reduced ALDH1L1 and reduced phospho-MST1 and phospho-YAP. YAP knockdown abolished the BM-MSC driven astrocyte prolif…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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