Vitamin D attenuates lung injury via stimulating epithelial repair, reducing epithelial cell apoptosis and inhibits TGF-beta induced epithelial to mesenchymal transition.
MouseEndotoxin/LPSC57BL/6Male and femaleIntragastric0.1, 1.5 and 10 mg/kgPretreatment for 14 days before intratracheal lipopolysaccharide
Model: Intratracheal lipopolysaccharide-induced acute lung injury in mildly vitamin D deficient mice; supported by primary human and murine type II alveolar epithelial cell work
Vitamin D supplementation promoted alveolar type II cell proliferation, inhibited apoptosis and inhibited epithelial to mesenchymal transition, attenuating lipopolysaccharide-induced lung injury; in vitro it stimulated epithelial scratch wound repair through vitamin D receptor dependent PI3K/Akt si…
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