Activated Vitamin D (incl Calcitriol) for Acute Kidney Injury (ACTIVATE-AKI)
Acute Kidney Injury
Enrolment: 150 · Results not recorded
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Drug · Active vitamin D3; vitamin D receptor agonist.
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Acute Kidney Injury
Enrolment: 150 · Results not recorded
Secondary Hyperparathyroidism
Enrolment: 13 · Results not recorded
Pityriasis Alba
Enrolment: 39 · Results not recorded
Kidney Failure · Secondary Hyperparathyroidism
Enrolment: 16 · Results not recorded
IgA Nephropathy
Enrolment: 10 · Results not recorded
Cardiorenal Syndrome · Chronic Allograft Nephropathy
Enrolment: 109 · Results not recorded
Postmenopausal Osteoporoses
Enrolment: 60 · Results not recorded
Psoriasis
Enrolment: 20 · Results not recorded
Secondary Hyperparathyroidism in Haemodialysis
Enrolment: 98 · Results not recorded
Breast Neoplasms · Postmenopausal Disorder
Enrolment: 60 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Acute spinal cord injury (specific model not stated in the abstract)
Calcitriol significantly improved BBB score at 12 weeks compared with injured controls, with more surviving ventral horn motor neurons, a significant regulatory effect on lymphocyte Division Index in response to myelin basic protein, and reduced IFN-gamma and IL-17A secretion and leukocyte infiltra…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Corneal epithelial debridement wound, circular wound approximately 2 mm diameter in the central cornea created with an Algerbrush II
At 12 and 18 hours after wounding, topical vitamin D significantly delayed wound closure by about 17% and increased neutrophil infiltration into the central cornea, with more neutrophils in the parawound and wound centre regions. Basal epithelial cell division, corneal nerve density and levels of V…
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Acute ethanol-induced intestinal barrier injury in mice, with parallel ethanol exposure of Caco-2 cell monolayers
Pre-treatment with 1,25(OH)2D3 ameliorated ethanol-induced barrier dysfunction, tight junction disruption, myosin light chain phosphorylation and reactive oxygen species generation. Mice on a vitamin D-sufficient diet had higher plasma 25(OH)D3 and were more resistant to acute ethanol-induced intes…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Intratracheal lipopolysaccharide-induced acute lung injury in mildly vitamin D deficient mice; supported by primary human and murine type II alveolar epithelial cell work
Vitamin D supplementation promoted alveolar type II cell proliferation, inhibited apoptosis and inhibited epithelial to mesenchymal transition, attenuating lipopolysaccharide-induced lung injury; in vitro it stimulated epithelial scratch wound repair through vitamin D receptor dependent PI3K/Akt si…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.