Deposition of Iron in the Bone Marrow of a Murine Model of Hematopoietic Acute Radiation Syndrome.
MouseRadiationC57BL/6J; separate GATA1-low myelofibrosis transgenic mice as a non-radiation marrow injury comparatorFemalen = n=16 per group for survival; n=1 to 5 per group per time po…Oral, in drinking water0.055 g/L in acidified drinking water, delivering approxima…Begun 2 days after irradiation
Model: Bilateral cobalt-60 gamma total body irradiation, midline tissue dose 7.79 Gy (LD70) at 0.6 Gy/min; a separate liver iron experiment used 6.85 Gy
Captopril increased 30 day survival from 12.5 percent to 62.5 percent (p<0.05) and improved recovery of red cells, reticulocytes, haemoglobin and erythroblastic islands, but did not alter the roughly 8 to 10 fold radiation-induced bone marrow iron deposition peaking around day 21 or most iron handl…
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