Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure
Preeclampsia
Enrolment: 90 · Results not recorded
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Drug · Angiotensin-converting enzyme inhibitor
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Preeclampsia
Enrolment: 90 · Results not recorded
Hypertension
Enrolment: 800 · Results not recorded
Cancer
Enrolment: 35 · Results not recorded
Cardiotoxicity · Acute Myeloid Leukaemia in Children · Bone Tumour
Enrolment: 245 · Results not recorded
Congenital Mitral Insufficiency
Enrolment: 122 · Results not recorded
Primary Aldosteronism
Enrolment: 150 · Results not recorded
9 studies reported at therapy level; 9 evidence entries itemised.
Model: single 13 Gy X-irradiation to the whole thorax at 1.43 Gy/min
All three ACE inhibitors prevented the increase in lung collagen synthesis at 7 months and lung morphology supported protection against fibrosis. Captopril and enalapril, but not fosinopril, also reduced morbidity from acute pneumonitis.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Bilateral cobalt-60 gamma total body irradiation, midline tissue dose 7.79 Gy (LD70) at 0.6 Gy/min; a separate liver iron experiment used 6.85 Gy
Captopril increased 30 day survival from 12.5 percent to 62.5 percent (p<0.05) and improved recovery of red cells, reticulocytes, haemoglobin and erythroblastic islands, but did not alter the roughly 8 to 10 fold radiation-induced bone marrow iron deposition peaking around day 21 or most iron handl…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Cobalt-60 gamma total body irradiation, 7.5 to 7.9 Gy at 0.615 Gy/min, haematopoietic acute radiation syndrome
Low-dose captopril (13 mg/kg/day) begun as late as 48 h after 7.9 Gy and continued for only 14 days raised 30-day survival to 62 per cent versus 6 to 12 per cent in vehicle controls, matching high-dose treatment. Survival was associated with recovery of bone marrow cellularity to about 90 per cent…
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
Model: Aristolochic acid I-induced acute nephropathy, 15 mg/kg per day intraperitoneally for 3 days to a cumulative dose of 45 mg/kg
Chymase inhibition, and particularly combined ACE and chymase inhibition, lowered renal angiotensin II, reduced serum blood urea nitrogen and creatinine, proteinuria, inflammatory cytokines and tubular injury, and reduced p-MEK/p-ERK1/2 activation, though injury was ameliorated rather than prevente…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Severe acute pancreatitis with associated lung injury induced by retrograde bile-pancreatic duct infusion of 5% sodium taurocholate at 0.1 mL per 100 g
Captopril pretreatment reduced pancreatic (9.1 to 5.8) and lung (3.7 to 2.6) histology scores, lung wet-to-dry ratio (5.74 to 4.25), Evans Blue extravasation, serum amylase (5695.7 to 3862.1 U/L) and lung angiotensin II (287.16 to 211.14 pg/mL), with lower AT1, RhoA, ROCK2 and MLCK expression but n…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Lipopolysaccharide-induced acute lung injury (7.5 mg/kg lipopolysaccharide intravenously); rat pulmonary microvascular endothelial cells stimulated with lipopolysaccharide in vitro
Captopril pretreatment attenuated lung pathology, reduced tumour necrosis factor-alpha and interleukin-6, lowered the angiotensin II to angiotensin-1-7 ratio and reduced the ACE to ACE2 ratio from 7.07 to 1.71 in vivo and 5.18 to 1.52 in vitro, with inhibition of p38 MAPK, ERK1/2 and JNK phosphoryl…
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Local irradiation of the rat heart and/or lungs, with endpoints at 8 weeks
Captopril improved breathing rate, cardiopulmonary density and structure and left ventricular end-diastolic pressure and reduced effusions and cardiac fibrosis, but only when the heart was included in the radiation field.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Dorsal scald burn produced by exposure to 90 degrees C water for 10 s (sham 25 degrees C)
Burn increased nNOS expression in frontal cortex, striatum and midbrain; captopril reduced nNOS in frontal cortex and midbrain but increased striatal and hippocampal nNOS relative to control.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.78. Machine-extracted fields require source verification.
Model: Single 10 Gy thorax-only irradiation of unanaesthetised rats, assessed at 2 months during development of radiation pneumonitis
Captopril at the vasoactive dose of 56 mg/kg/day mitigated radiation-induced pulmonary vascular injury, improving pulmonary vascular resistance, pulmonary arterial distensibility and distal vessel density, and remained effective when started 2 weeks after exposure. The lower 17 mg/kg/day dose was n…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.