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PRECLINICAL PUBLICATION · 2020

Overexpression of Rictor in the injured spinal cord promotes functional recovery in a rat model of spinal cord injury.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 32232913 ↗2020Reported benefit

Overexpression of Rictor in the injured spinal cord promotes functional recovery in a rat model of spinal cord injury.

RatSpinal cord injuryContusionSprague-DawleyFemaleIntraspinal cord injectionAfter contusion injury (exact interval not stated in abstract)

Model: Spinal cord contusion at the T9 to T10 level

Rictor overexpression attenuated the acute inflammatory response and cell death, shifted macrophages around the lesion from M1 to M2, increased neurogenesis at the lesion epicentre and promoted tissue repair and functional recovery relative to control vector.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.