THERAPY DOSSIER · th-9c92310f27d4

Rictor overexpression lentiviral vector

Biologic · Rictor (mTORC2 component) overexpression lentiviral vector; gene-delivery construct.

Evidence & regulatory context

Mechanism: Rictor (mTORC2 component) overexpression lentiviral vector; gene-delivery construct.
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32232913 ↗2020Reported benefit

Overexpression of Rictor in the injured spinal cord promotes functional recovery in a rat model of spinal cord injury.

RatSpinal cord injuryContusionSprague-DawleyFemaleIntraspinal cord injectionAfter contusion injury (exact interval not stated in abstract)

Model: Spinal cord contusion at the T9 to T10 level

Rictor overexpression attenuated the acute inflammatory response and cell death, shifted macrophages around the lesion from M1 to M2, increased neurogenesis at the lesion epicentre and promoted tissue repair and functional recovery relative to control vector.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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