Maternal alcoholism and neonatal hypoxia-ischemia: Neuroprotection by stilbenoid polyphenols.
RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarMale and female pupsMaternal oral administration in drinking water0.15 mg/kg/day for each polyphenol; alcohol 0.5 g/kg/dayMaternal supplementation throughout pregnancy and breastfeeding, before and aft…
Model: Postnatal day 7 hypoxia-ischaemia in a context of moderate maternal alcohol exposure (0.5 g/kg/day in drinking water during pregnancy and lactation)
Moderate maternal alcohol exposure did not increase MRI lesion volume but worsened motor impairment. Resveratrol did not reverse the deleterious effects, whereas piceatannol restored all sensorimotor and cognitive functions, at a dose corresponding to about one passion fruit per day for a pregnant…
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