FTY720 Attenuates Neuropathic Pain after Spinal Cord Injury by Decreasing Systemic and Local Inflammation in a Rat Spinal Cord Compression Model.
RatSpinal cord injuryCompressionSprague-DawleyFemalen = 15 rats per group at randomisation (vehicle n = 15, FTY720…Intraperitoneal1.5 mg/kg diluted in saline24 hours after injury
Model: Thoracic spinal cord injury at T6 by 1 minute extradural compression with a modified aneurysm clip, closing force 30 g, after T6 and T7 laminectomy
FTY720 significantly raised the mechanical withdrawal threshold, improved BBB motor score and lowered mortality. It reduced lesion length and volume, decreased circulating CD3 positive lymphocytes at day 3, reduced Iba1 and CD68 positive cells rostral and caudal to the lesion at day 7, reduced fibr…
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