Effects of Preinjury and Postinjury Exposure to Caffeine in a Rat Model of Traumatic Brain Injury.
RatTBIFluid percussionChronic pre-injury exposure; an acute bolus immediately following injury; and c…
Model: Fluid percussion traumatic brain injury
An acute bolus of caffeine given immediately after fluid percussion injury dose-dependently prevented lethal apnoea regardless of chronic pre-injury caffeine exposure, and had no detrimental effect on motor performance after sublethal injury. Chronic caffeine treatment after injury, but not caffein…
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