Caffeine Versus Probiotic as Adjuvant Therapy for Preterm Neonates With Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia
Enrolment: 90 · Results not recorded
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Drug · Adenosine receptor antagonist (ANTAGONIST)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Bronchopulmonary Dysplasia
Enrolment: 90 · Results not recorded
Cocaine Related Disorders
Enrolment: 85 · Results not recorded
Retinopathy of Prematurity
Enrolment: 14 · Results not recorded
Caffeine · Placebo
Enrolment: 16 · Results not recorded
Fatigue · Mental Alertness
Enrolment: 128 · Results not recorded
Obesity
Enrolment: 15 · Results not recorded
Morbid Obesity
Enrolment: 218 · Results not recorded
AOD Effects and Consequences
Enrolment: 16 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Fluid percussion traumatic brain injury
An acute bolus of caffeine given immediately after fluid percussion injury dose-dependently prevented lethal apnoea regardless of chronic pre-injury caffeine exposure, and had no detrimental effect on motor performance after sublethal injury. Chronic caffeine treatment after injury, but not caffein…
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Model: Unilateral frontal WRAIR penetrating ballistic-like brain injury (PBBI) in the right hemisphere at moderate (7% PBBI) or severe (10% PBBI) injury level
Acute caffeine had no significant effect on motor or cognitive outcome but increased thigmotaxis after 10% PBBI, suggesting worsened anxiety or attention. Chronic caffeine improved motor outcome at 7 and 10 days post-injury in the 7% PBBI group but significantly increased Morris water maze latency…
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Model: Severe whole body blast injury from a high-intensity blast wave
Chronic caffeine alleviated blast-induced traumatic brain injury, but both chronic and acute caffeine worsened blast-induced lung injury and increased cumulative and time-segmented mortality, whereas withdrawing caffeine before injury gave mortality and lung outcomes similar to water-treated mice w…
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Model: Lateral fluid percussion injury, 5 mm trephine at bregma -4.5 mm AP, +2.8 mm ML, 21-23 ms fluid pulse at peak pressure 1.97 +/- 0.02 ATM
Untreated severe injury produced 47 per cent acute mortality (7 of 15 rats) with prolonged apnoea in non-survivors. Caffeine given within 1 minute of injury prevented prolonged apnoea and completely prevented acute mortality in 8 treated rats. Neuromotor performance on Neuroscore and open field was…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.