Extracellular nucleic acid scavenging rescues rats from sulfur mustard analog-induced lung injury and mortality.
RatChemical/toxinSprague-DawleyMaleIntraperitoneal10 mg/kg2 hours after CEES exposure
Model: Acute lung injury and ARDS from nose-only inhalation of aerosolised CEES (2-chloroethyl ethyl sulfide) 10% in ethanol for 15 minutes under ketamine, xylazine and acepromazine anaesthesia
HDMBr completely rescued the 12 hour mortality seen in CEES-exposed animals (control survival about 50%), normalised extracellular nucleic acids, improved oxygenation from a PaO2/FiO2 of about 150 to above 300, reduced alveolar-capillary leak, inflammatory cytokines, HMGB1, tissue factor, PAI-1 and…
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