Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Chemical/toxin · Haemorrhage/shock
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Preclinical/no trial
- ChEMBL max phase
- 2 / 4 (development scale, not regulatory approval)
- Synonyms
- Hexadimethrine bromide; Polybrene; NSC-118096; NSC-25133; Bromure d'hexadimethrine; Bromuro de hexadimetrina
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
RatChemical/toxinSprague-DawleyMaleIntraperitoneal10 mg/kg2 hours after CEES exposure
Model: Acute lung injury and ARDS from nose-only inhalation of aerosolised CEES (2-chloroethyl ethyl sulfide) 10% in ethanol for 15 minutes under ketamine, xylazine and acepromazine anaesthesia
HDMBr completely rescued the 12 hour mortality seen in CEES-exposed animals (control survival about 50%), normalised extracellular nucleic acids, improved oxygenation from a PaO2/FiO2 of about 150 to above 300, reduced alveolar-capillary leak, inflammatory cytokines, HMGB1, tissue factor, PAI-1 and…
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
RatHaemorrhage/shockUnspecifiedWistarn = 4 to 8 animals per group in the reported histology and mark…Intravenous bolus administered over 10 minutes1 to 4 mg/kg dissolved in 250 microlitres salineAfter the haemorrhage phase was completed, described by the authors as a clinic…
Model: Rodent trauma and haemorrhagic shock model with varying degrees of tissue injury, plus purified mitochondrial DNA injection experiments
Hexadimethrine bromide significantly attenuated the rise in circulating nuclear DNA at 1 mg/kg with a non-significant trend towards reduced mitochondrial DNA, normalised phosphorylated NF-kappaB at 2 and 4 mg/kg, and improved lung histology, cell death and oxidative injury markers in a dose-depende…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
