Neuronal brain injury after cerebral ischemic stroke is ameliorated after subsequent administration of (R)-ketamine, but not (S)-ketamine.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6Male10 mg/kgPost-treatment at 1 hour and 24 hours after occlusion; a separate protocol gave…
Model: Middle cerebral artery occlusion model of ischaemic stroke
(R)-ketamine attenuated brain injury and behavioural abnormalities whether given after or before and after occlusion, whereas (S)-ketamine at the same dose had no effect.
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