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PRECLINICAL PUBLICATION · 2020

Neuronal brain injury after cerebral ischemic stroke is ameliorated after subsequent administration of (R)-ketamine, but not (S)-ketamine.

Mouse / Ischaemia-reperfusion

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 32156500 ↗2020Mixed findings

Neuronal brain injury after cerebral ischemic stroke is ameliorated after subsequent administration of (R)-ketamine, but not (S)-ketamine.

MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6Male10 mg/kgPost-treatment at 1 hour and 24 hours after occlusion; a separate protocol gave…

Model: Middle cerebral artery occlusion model of ischaemic stroke

(R)-ketamine attenuated brain injury and behavioural abnormalities whether given after or before and after occlusion, whereas (S)-ketamine at the same dose had no effect.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.