MSCs-Derived Exosomes Attenuate Acute Brain Injury and Inhibit Microglial Inflammation by Reversing CysLT2R-ERK1/2 Mediated Microglia M1 Polarization.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMaleTail vein (intravenous)After occlusion and reperfusion surgery; outcomes assessed at 7 days
Model: Middle cerebral artery occlusion and reperfusion; in vitro oxygen-glucose deprivation and leukotriene exposure in microglia
Exosome treatment improved motor, learning and memory performance at 7 days, reduced pro-inflammatory factors while increasing anti-inflammatory cytokines and neurotrophic factors, inhibited M1 polarisation and increased M2 microglia, and downregulated CysLT receptor expression and ERK1/2 phosphory…
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