Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Ischaemia-reperfusion
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 10
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
The Effectiveness of Mesenchymal Stem Cell-Derived Exosome Therapy in Improving Endothelial Dysfunction in Postpartum Mothers With a History of Preeclampsia
Preeclampsia · Postpartum · Endothelial Injury · Exosome Multiomics · Cell Therapy
Enrolment: 80 · Results not recorded
Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles for Hospitalized Patients With Moderate-to-Severe ARDS: A Phase III Clinical Trial
Acute Respiratory Distress Syndrome · ARDS
Enrolment: 970 · Results not recorded
Mesenchymal Stromal/Stem Cells-Derived Exosomes (MSC-Exos) Therapy for Type 2 Diabetes Mellitus Patients
Type 2 Diabetes Mellitus
Enrolment: 50 · Results not recorded
Application of Mesenchymal Stem Cells Derived Exosomes in Skin Rejuvenation
Anti Aging
Enrolment: 20 · Results not recorded
Safety and Efficacy of Allogenic Mesenchymal Stem Cells Derived Exosome on Disability of Patients With Acute Ischemic Stroke
Cerebrovascular Disorders
Enrolment: 5 · Results not recorded
Safety of Injection of Placental Mesenchymal Stem Cell Derived Exosomes for Treatment of Resistant Perianal Fistula in Crohn's Patients
Perianal Fistula in Patients With Crohn's Disease
Enrolment: 80 · Results not recorded
Evaluation of Mesenchymal Stem Cell-Derived Exosomes Versus Platelet-Rich Fibrin (PRF) in Post-Extraction Socket Healing
Alveolar Bone Loss · Tooth Extraction · Bone Regeneration
Enrolment: 40 · Results not recorded
Safety and Preliminary Efficacy of Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Adult Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus (T2DM)
Enrolment: 66 · Results not recorded
Intrathecal Injection of Human Autologous Mesenchymal Stromal Cells Derived Extracellular Vesicles for the Treatment of Syringomyelia
Syringomyelia
Enrolment: 18 · Results not recorded
Adia Med of Winter Park LLC Chronic Kidney Disease Research Study
Chronic Kidney Disease · CKD
Enrolment: 100 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMaleTail vein (intravenous)After occlusion and reperfusion surgery; outcomes assessed at 7 days
Model: Middle cerebral artery occlusion and reperfusion; in vitro oxygen-glucose deprivation and leukotriene exposure in microglia
Exosome treatment improved motor, learning and memory performance at 7 days, reduced pro-inflammatory factors while increasing anti-inflammatory cytokines and neurotrophic factors, inhibited M1 polarisation and increased M2 microglia, and downregulated CysLT receptor expression and ERK1/2 phosphory…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
