Hidden Cardiotoxicity of Rofecoxib Can be Revealed in Experimental Models of Ischemia/Reperfusion.
RatIschaemia-reperfusionCardiacWistarMalePretreatment for four weeks before ischaemia/reperfusion
Model: 30 min coronary artery occlusion followed by 120 min reperfusion, with or without ischaemic preconditioning; isolated papillary muscle and adult cardiac myocyte simulated ischaemia/reperfusion
Rofecoxib increased arrhythmias including ventricular fibrillation and prolonged action potential duration during ischaemia/reperfusion, and increased acute mortality, but decreased infarct size and increased survival of cardiac myocytes subjected to simulated ischaemia/reperfusion. The proarrhythm…
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