Melatonin receptor agonist ramelteon attenuates mouse acute and chronic ischemic brain injury.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)Oral3.0 mg/kgEffective when given up to 4 h after the onset of ischaemia
Model: Middle cerebral artery occlusion for acute focal cerebral ischaemia; photothrombosis for chronic ischaemic brain injury
Ramelteon significantly attenuated ischaemic injury in both acute and chronic models, with efficacy and time window comparable to edaravone. Protection was blocked by the melatonin receptor antagonist 4-P-PDOT and compromised by the autophagy activator rapamycin.
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