Melatonin Replacement for Treatment of Sleep Disruption
Insomnia · Spinal Cord Injury · Tetraplegia · Sleep Disorders
Enrolment: 12 · Results not recorded
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Drug · Melatonin receptor agonist
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Insomnia · Spinal Cord Injury · Tetraplegia · Sleep Disorders
Enrolment: 12 · Results not recorded
Circadian Rhythm Disorders
Enrolment: 61 · Results not recorded
Insomnia
Enrolment: 33 · Results not recorded
Seasonal Affective Disorder
Enrolment: 50 · Results not recorded
Delirium
Enrolment: 240 · Results not recorded
Major Depressive Disorder · Insomnia
Enrolment: 29 · Results not recorded
Chronic Insomnia
Enrolment: 1081 · Results not recorded
Sleep Initiation and Maintenance Disorders
Enrolment: 378 · Results not recorded
Insomnia
Enrolment: 30 · Results not recorded
Delirium · Sleep Deprivation
Enrolment: 120 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Middle cerebral artery occlusion for acute focal cerebral ischaemia; photothrombosis for chronic ischaemic brain injury
Ramelteon significantly attenuated ischaemic injury in both acute and chronic models, with efficacy and time window comparable to edaravone. Protection was blocked by the melatonin receptor antagonist 4-P-PDOT and compromised by the autophagy activator rapamycin.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.