Novel method for producing standard subacute gastric ulcer in rats and for the quantitative evaluation of the healing process. Effect of several drugs on healing.
RatOtherInbred strain not specifiedFemaleOral for the study drugs; N-ethylmaleimide subcutaneousDose-dependent effects reported; specific dose levels not s…30 min and 24 h after gastric puncture
Model: Subacute gastric ulcer produced by transoral catheter-guided needle puncture of the gastric wall under ether anaesthesia in fasted rats
Cimetidine, famotidine, pirenzepine and sucralfate dose-dependently and significantly increased the healing rate of subacute gastric ulcers. Naproxen, piroxicam, indomethacin and ibuprofen significantly delayed healing, acetylsalicylic acid had no significant effect, and 0.5 molar hydrochloric acid…
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