Enhanced post-traumatic headache-like behaviors and diminished contribution of peripheral CGRP in female rats following a mild closed head injury.
RatTBIWeight-drop / impact-accelerationSprague-DawleyFemalen = 126 injured and 28 sham female rats, plus separate cohorts…SystemicSumatriptan 1 mg/kg; mouse anti-CGRP monoclonal antibody 30…Sumatriptan given acutely; anti-CGRP antibody given early and for a prolonged p…
Model: Mild closed head injury using a weight-drop device, with sham controls; glyceryl trinitrate 100 micrograms/kg intraperitoneally used as a headache trigger
Female rats developed cephalic mechanical hyperalgesia that resolved by 4 weeks. Sumatriptan ameliorated cephalic hypersensitivity whereas early and prolonged anti-CGRP antibody treatment did not. After resolution, glyceryl trinitrate renewed cephalic and extracephalic hypersensitivity, which sumat…
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