THERAPY DOSSIER · th-1e5946bf3fad

Sumatriptan and anti-calcitonin gene-related peptide monoclonal antibody

Drug · Selective serotonin 5-HT1B and 5-HT1D receptor agonist (AGONIST; direct interaction, disease efficacy)

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This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Selective serotonin 5-HT1B and 5-HT1D receptor agonist (AGONIST; direct interaction, disease efficacy)
Target: CHEMBL1898 (AGONIST); CHEMBL1983 (AGONIST)
Injury models: TBI
Reported indication: Not recorded
First approval: 1992
Development stage: Not recorded
ChEMBL record: CHEMBL128 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Sumatriptan; Imitrex; Tosymra; DFN-11; Imigran; Treximet; Sumatriptan succinate; N02CC01
Note: Not recorded

Clinical trials 10

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00385008 ↗PHASE3completed

Absorption and transit of TREXIMA (sumatriptan/naproxen) and RELPAX in migraine

Migraine Disorders

Enrolment: 20 · Results not recorded

NCT00382993 ↗PHASE3completed

Sumatriptan succinate/naproxen sodium in migraine with poor response to short-acting triptans

Migraine Disorders

Enrolment: 169 · Results not recorded

NCT01814189 ↗PHASE3completed

Oral sumatriptan plus oral promethazine in migraine treatment

Migraine With Aura · Migraine Without Aura

Enrolment: 350 · Results not recorded

NCT03185143 ↗PHASE2/PHASE3completed

Low-dose naltrexone/acetaminophen versus sumatriptan in acute migraine with nausea

Migraine With and Without Aura

Enrolment: 36 · Results not recorded

NCT00892203 ↗PHASE2completed

BGG492 versus sumatriptan and placebo in acute migraine

Migraine

Enrolment: 75 · Results not recorded

NCT00530517 ↗PHASE2completed

Subcutaneous sumatriptan via the Intraject system in acute migraine attack

Migraine Headache

Enrolment: 54 · Results not recorded

NCT03076970 ↗PHASE1completed

Lasmiditan coadministered with sumatriptan (Imitrex) in healthy subjects

Migraine

Enrolment: 42 · Results not recorded

NCT00720018 ↗PHASE1completed

Pharmacokinetics of NP101 sumatriptan iontophoretic transdermal patch

Migraine Disorders

Enrolment: 4 · Results not recorded

NCT01381497 ↗Phase not recordedcompleted

Migraine work productivity with sumatriptan/naproxen sodium or triptan monotherapy

Migraine Disorders

Enrolment: 1 · Results not recorded

NCT03156920 ↗Phase not recordedcompleted

Pretreatment with sumatriptan on cilostazol-induced headache in healthy volunteers

Migraine

Enrolment: 30 · Results not recorded

Preclinical evidence 3

3 studies reported at therapy level; 3 evidence entries itemised.

PMID 32077327 ↗2020Mixed findings

Enhanced post-traumatic headache-like behaviors and diminished contribution of peripheral CGRP in female rats following a mild closed head injury.

RatTBIWeight-drop / impact-accelerationSprague-DawleyFemalen = 126 injured and 28 sham female rats, plus separate cohorts…SystemicSumatriptan 1 mg/kg; mouse anti-CGRP monoclonal antibody 30…Sumatriptan given acutely; anti-CGRP antibody given early and for a prolonged p…

Model: Mild closed head injury using a weight-drop device, with sham controls; glyceryl trinitrate 100 micrograms/kg intraperitoneally used as a headache trigger

Female rats developed cephalic mechanical hyperalgesia that resolved by 4 weeks. Sumatriptan ameliorated cephalic hypersensitivity whereas early and prolonged anti-CGRP antibody treatment did not. After resolution, glyceryl trinitrate renewed cephalic and extracephalic hypersensitivity, which sumat…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

PMID 27899434 ↗2016Reported benefit

Development of CGRP-dependent pain and headache related behaviours in a rat model of concussion: Implications for mechanisms of post-traumatic headache.

RatTBIWeight-drop / impact-accelerationSprague-Dawley (Taconic)Malen = 128 male rats in total, 6 to 8 per group, with 5 animals ex…IntraperitonealAnti-CGRP antibody and isotype control IgG 30 mg/kg in 0.54…Antibody first administered immediately after injury induction; sumatriptan giv…

Model: Mild closed head injury concussion by weight drop, with a 250 g weight dropped through a tube from 80 cm onto the centre of the head under 3% isoflurane with the animal chest-down on a foam sponge

Concussion produced cephalic tactile hypersensitivity, sumatriptan-conditioned place preference and prolonged glyceryl trinitrate hypersensitivity, all attenuated by acute sumatriptan and chronic anti-CGRP antibody, although the antibody had no effect on extracephalic hindpaw hypersensitivity.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

PMID 26472135 ↗2015Reported benefit

Trigeminal Pain Molecules, Allodynia, and Photosensitivity Are Pharmacologically and Genetically Modulated in a Model of Traumatic Brain Injury.

MouseTBIControlled cortical impactC57BL (from MeSH indexing); wild-type and inducible nitric oxide synthase (iNOS) knockout miceMaleTreatment effects compared with vehicle at 2 weeks post injury; genetic compari…

Model: Controlled cortical impact traumatic brain injury, used as a model of post-traumatic headache

MK8825 and sumatriptan both increased allodynic thresholds after controlled cortical impact compared with vehicle (P<0.01) and reduced iNOS messenger RNA and immunoreactivity in the trigeminal nucleus caudalis and ganglia (P<0.01). Photosensitivity was attenuated by MK8825 and in iNOS knockouts (P<…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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