Trehalose attenuates renal ischemia-reperfusion injury by enhancing autophagy and inhibiting oxidative stress and inflammation.
MouseIschaemia-reperfusionRenalC57BL/6JMaleIntraperitoneal2 g/kgPretreatment beginning 3 days before renal ischaemia-reperfusion surgery
Model: Renal ischaemia-reperfusion surgery in vivo; mouse proximal tubular cells under hypoxia/reoxygenation in vitro
Trehalose pretreatment improved renal histology and function, blocked the rise in kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin, activated autophagy, and inhibited ischaemia-reperfusion-induced apoptosis, oxidative stress and inflammation. In vitro it activated autophagy a…
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