Lagricel Ofteno vs Thealoz Duo (trehalose) for Corneal Re-epithelialization After PRK
Photorefractive Keratectomy · Corneal De-epithelialization
Enrolment: 96 · Results not recorded
Loading the evidence…
Nutraceutical
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Photorefractive Keratectomy · Corneal De-epithelialization
Enrolment: 96 · Results not recorded
Dry Eye Disease
Enrolment: 30 · Results not recorded
Alzheimer's Disease
Enrolment: 0 · Results not recorded
Neuronal Ceroid-Lipofuscinoses
Enrolment: 8 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Renal ischaemia-reperfusion surgery in vivo; mouse proximal tubular cells under hypoxia/reoxygenation in vitro
Trehalose pretreatment improved renal histology and function, blocked the rise in kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin, activated autophagy, and inhibited ischaemia-reperfusion-induced apoptosis, oxidative stress and inflammation. In vitro it activated autophagy a…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Laparotomy with a microclip (125 g pressure) on the superior mesenteric artery, 40 minutes of ischaemia followed by 3 hours of reperfusion; sham animals underwent laparotomy without clipping
Trehalose reduced the mucosal pathology score from 25 plus or minus 4 with saline to 10 plus or minus 2 (p<0.01) and abolished villus IgM and C3 deposition, while lipid peroxidation was unchanged (malondialdehyde 1.8 plus or minus 0.21 versus 1.99 plus or minus 0.31 micromolar; 4-HNE positive villi…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.