Riluzole improves functional recovery after acute spinal cord injury in rats and may be associated with changes in spinal microglia/macrophages polarization.
RatSpinal cord injuryContusionWistarFemalen = n = 18 per group for locomotor testingIntraperitoneal4 mg/kgImmediately following spinal cord injury
Model: Acute contusive spinal cord injury
Riluzole-treated rats had significantly higher locomotor scores, smaller spinal cavities, higher myelin basic protein and neurofilament-200 immunoreactivity, lower proinflammatory cytokines at 7 days, more CD206-positive and fewer iNOS-positive cells, with upregulated M2 and downregulated M1 marker…
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