Multi-Center RCT of Riluzole in Acute Spinal Cord Injury
Spinal Cord Injury
Enrolment: 193 · Results not recorded
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Drug · Sodium channel alpha subunit blocker (BLOCKER)
3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Spinal Cord Injury
Enrolment: 193 · Results not recorded
Spinal Cord Injury
Enrolment: 90 · Results not recorded
Spinal Cord Injury
Enrolment: 36 · Results not recorded
Cerebellar Ataxia
Enrolment: 60 · Results not recorded
SMA
Enrolment: 141 · Results not recorded
Amyotrophic Lateral Sclerosis
Enrolment: 219 · Results not recorded
Atrial Fibrillation Paroxysmal
Enrolment: 78 · Results not recorded
Major Depressive Disorder
Enrolment: 21 · Results not recorded
Melanoma (Skin)
Enrolment: 15 · Results not recorded
Amyotrophic Lateral Sclerosis
Enrolment: 22 · Results not recorded
6 studies reported at therapy level; 7 evidence entries itemised.
Model: Unilateral (hemicord) contusion of the lower cervical spinal cord at C7, produced under ketamine/xylazine anaesthesia by releasing a 10 g weight from a height of 25 mm onto a 1.55 mm diameter impactor positioned on the dura near the left C8 nerve root, producing ipsilateral but not contralateral primary haemorrhage
Treatment-associated mortality was 30% (3/10) control, 30% (3/10) riluzole, 12.5% (1/8) hypothermia and 0% (0/7) glibenclamide. All three treatments improved mBBB scores versus control during the last four weeks; riluzole-treated rats underperformed for the first two weeks. On beam balance, hypothe…
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Model: Mid-thoracic spinal cord compression injury
Systemic riluzole reversed below-level cutaneous hypersensitivity in spinal cord injured rats.
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Model: Acute contusive spinal cord injury
Riluzole-treated rats had significantly higher locomotor scores, smaller spinal cavities, higher myelin basic protein and neurofilament-200 immunoreactivity, lower proinflammatory cytokines at 7 days, more CD206-positive and fewer iNOS-positive cells, with upregulated M2 and downregulated M1 marker…
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Model: Sciatic nerve crush injury
Both acute and chronic riluzole administration immediately after sciatic nerve crush significantly delayed regeneration and reduced motor functional outcome, indicating that even a single early dose can delay motor recovery. The authors suggest this effect is not dependent on the anti-nociceptive a…
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Model: In vitro excitotoxic injury of the isolated neonatal spinal cord by transient (1 h) application of kainate 0.05 to 0.1 mM
Riluzole partially reduced pyknotic cell numbers in grey matter when applied continuously, but motoneurons remained vulnerable and fictive locomotion did not recover under any protocol, including 3 h application or co-application with kainate.
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Model: Laminectomy at T12 followed by compressive trauma to induce thoracic spinal cord injury
The combination of riluzole and dantrolene produced significant locomotor recovery compared with all other groups, with more NeuN positive neurons adjacent to the injury epicentre and TUNEL staining similar to uninjured animals, indicating a synergistic reduction in apoptotic cell death
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