Modulation of Post-Traumatic Immune Response Using the IL-1 Receptor Antagonist Anakinra for Improved Visual Outcomes.
MouseTBIBlast / overpressureC57BL/6JMaleIntraperitonealStarted one week before injury and continued for three weeks after injury
Model: Blast-mediated traumatic brain injury, three 20 psi blast waves directed at the head with the body shielded, one hour between blasts
Blast exposure increased retinal proinflammatory cytokine expression and activated microglia and macroglia. Anakinra preserved retinal ganglion cell function and retinal ganglion cell layer thickness compared with saline, with a trend toward decreased optic nerve damage.
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