Biologic Therapy (Anakinra) to Prevent Osteoarthritis After ACL Injury
Anterior Cruciate Ligament Injuries
Enrolment: 32 · Results not recorded
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Biologic · Interleukin-1 receptor antagonist (ANTAGONIST; direct interaction)
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Anterior Cruciate Ligament Injuries
Enrolment: 32 · Results not recorded
COVID-19 Infection
Enrolment: 71 · Results not recorded
Community-acquired Pneumonia · Influenza · COVID-19
Enrolment: 20000 · Results not recorded
COVID-19
Enrolment: 606 · Results not recorded
Pericarditis
Enrolment: 48 · Results not recorded
FMF
Enrolment: 50 · Results not recorded
PEDIATRIC ACUTE MYOCARDITIS
Enrolment: 110 · Results not recorded
Multisystem Inflammatory Syndrome-Children
Enrolment: 73 · Results not recorded
Polymyositis · Dermatomyositis · Inclusion Body Myositis
Enrolment not recorded · Results not recorded
Acute Myocardial Infarction
Enrolment: 99 · Results not recorded
Pancreatic Adenocarcinoma
Enrolment: 24 · Results not recorded
Uveitis
Enrolment: 112 · Results not recorded
Alcoholic Hepatitis
Enrolment: 147 · Results not recorded
Multiple Myeloma
Enrolment: 9 · Results not recorded
Polycystic Ovary Syndrome
Enrolment: 18 · Results not recorded
Autoimmune Inner Ear Disease · Meniere's Disease
Enrolment: 57 · Results not recorded
Kawasaki Disease · Children
Enrolment: 16 · Results not recorded
Heart Failure With Normal Ejection Fraction
Enrolment: 31 · Results not recorded
Asthma, Allergic
Enrolment: 0 · Results not recorded
Diabetes Mellitus, Type 1
Enrolment: 22 · Results not recorded
10 studies reported at therapy level; 10 evidence entries itemised.
Model: Closed intra-articular fracture of the left tibial plateau produced by compressive loading (10 N preload, loading at 20 N/s, indenter displacement limited to 2.7 mm) with no fixation or surgical intervention; assessment at 8 weeks post-injury
Local intra-articular IL-1Ra prevented cartilage degeneration, with no significant Mankin difference between fractured and contralateral limbs (p=0.37) and lower fractured-limb Mankin scores than saline (p=0.03). Local sTNFRII did not differ from saline (p=0.38). Systemic IL-1Ra worsened outcomes,…
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Model: Distal tibia fracture under isoflurane anaesthesia followed by hindlimb cast immobilisation for 4 weeks, a model of complex regional pain syndrome
At 4 weeks after fracture, systemic NK1 antagonist, anakinra and anti-NGF each reduced or abolished hindpaw allodynia and unweighting and reduced the interpaw temperature difference, with effect sizes of 30 to 50 per cent for warmth and no significant effect on edema. By 16 weeks the systemic treat…
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Model: Blast-mediated traumatic brain injury, three 20 psi blast waves directed at the head with the body shielded, one hour between blasts
Blast exposure increased retinal proinflammatory cytokine expression and activated microglia and macroglia. Anakinra preserved retinal ganglion cell function and retinal ganglion cell layer thickness compared with saline, with a trend toward decreased optic nerve damage.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Spinal cord contusion injury
IL-1ra blocked morphine-induced attenuation of locomotor recovery but alone worsened recovery and increased tissue loss.
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Model: Peripheral nerve injury (spinal nerve transection and neuroma models)
IL-1ra prevented and attenuated neuropathic pain behaviour and reduced ectopic neuronal activity after nerve injury.
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Model: Intracerebral lipopolysaccharide injection causing diffuse inflammatory white matter injury
Multimodal MRI, and diffusion tensor imaging in particular, detected an early neuroprotective effect of IL-1Ra 24 h after treatment, corroborated by immunohistochemistry and inflammatory and cell death mRNA expression.
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Model: Splinted full-thickness excisional wound model with two 6 mm punch biopsy wounds per animal stented with 7 mm silicone splints
Treated wounds were significantly smaller than vehicle-treated wounds at day 7 (p less than 0.02) and day 14 (p less than 0.03), with the day 21 difference not significant, and showed significantly less neutrophil and macrophage infiltration.
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Model: Controlled cortical impact or sham surgery at postnatal day 21, approximating a toddler-aged child; impact device, velocity, depth and dwell time not available
IL-1Ra reduced seizure susceptibility at 2 weeks post-injury versus vehicle and lowered hippocampal astrogliosis. In the chronic arm, IL-1Ra-treated injured mice showed improved spatial memory at 4 months, fewer evoked seizures at 6 months and greater preservation of cortical tissue.
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Model: Lipopolysaccharide (200 ug/kg i.p.) followed 4 h later by permanent right common carotid artery ligation plus 8% oxygen hypoxia (term-equivalent neonatal encephalopathy)
IL-1ra reduced total lesion volume from 76.7 +/- 11.7 mm3 to 17.5 +/- 2.4 mm3 at post-natal day 20 after combined lipopolysaccharide and hypoxia-ischaemia, confirming a causal role for IL-1beta.
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Model: Corneal epithelial debridement wound in streptozotocin-induced type 1 diabetic mice
Local recombinant IL-1Ra partially but significantly reversed delayed re-epithelialisation and the associated cellular and neural changes in diabetic corneas; exogenous CXCL10 alleviated delayed healing in diabetic corneas but attenuated healing in normal corneas.
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