Rapid Freezing Enables Aminoglycosides To Eradicate Bacterial Persisters via Enhancing Mechanosensitive Channel MscL-Mediated Antibiotic Uptake.
MouseWoundICRMale
Model: Mouse acute skin wound model infected with antibiotic-tolerant bacterial persisters
Ten seconds of liquid nitrogen freezing enhanced the bactericidal action of aminoglycosides by 2 to 6 orders of magnitude against many Gram-negative pathogens, with weaker potentiation against Gram-positive bacteria, and as a proof of concept potentiated killing of persisters in a mouse acute skin…
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