THERAPY DOSSIER · th-ede9524ab1a1

Aminoglycoside antibiotics combined with 10-second liquid nitrogen freezing

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32047133 ↗2020Reported benefit

Rapid Freezing Enables Aminoglycosides To Eradicate Bacterial Persisters via Enhancing Mechanosensitive Channel MscL-Mediated Antibiotic Uptake.

MouseWoundICRMale

Model: Mouse acute skin wound model infected with antibiotic-tolerant bacterial persisters

Ten seconds of liquid nitrogen freezing enhanced the bactericidal action of aminoglycosides by 2 to 6 orders of magnitude against many Gram-negative pathogens, with weaker potentiation against Gram-positive bacteria, and as a proof of concept potentiated killing of persisters in a mouse acute skin…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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