The effect of preconditioning with high-intensity training on tissue levels of G-CSF, its receptor and C-kit after an acute myocardial infarction in male rats.
RatChemical/toxinWistarMalen = 20 rats, 5 per group in 4 groupsNot applicable, treadmill runningTreadmill intervals at 35 to 45 m/min for high bouts (appro…Preconditioning, two weeks of training completed before injury; myocardial infa…
Model: Isoprenaline-induced acute myocardial infarction (150 mg/kg subcutaneously on two consecutive days, 24 h apart)
Cardiac injury markers rose after isoprenaline in both infarcted groups but were significantly lower in the trained plus infarcted group than in the infarcted group. Training alone raised cardiac G-CSF and C-kit relative to control, and the rise in G-CSF, G-CSFR and C-kit after infarction was blunt…
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