THERAPY DOSSIER · th-67922d09a993

High-intensity interval treadmill training (exercise preconditioning)

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03942588 ↗Injury indicationNAcompleted

High-intensity Interval Training for Adults With Chronic Stroke Impairments: A Pilot Feasibility Study

Stroke, Ischemic · Stroke Hemorrhagic

Enrolment: 17 · Results not recorded

NCT06264336 ↗NAcompleted

Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis

Multiple Sclerosis

Enrolment: 12 · Results not recorded

NCT04835740 ↗NAcompleted

Effects of High-intensity Interval Aerobic Training on Balance, Walking Capacity, and Quality of Life in Patients With Sub-acute Stroke

Stroke, Ischemic · Cerebrovascular Accident

Enrolment: 50 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32046645 ↗2020Reported benefit

The effect of preconditioning with high-intensity training on tissue levels of G-CSF, its receptor and C-kit after an acute myocardial infarction in male rats.

RatChemical/toxinWistarMalen = 20 rats, 5 per group in 4 groupsNot applicable, treadmill runningTreadmill intervals at 35 to 45 m/min for high bouts (appro…Preconditioning, two weeks of training completed before injury; myocardial infa…

Model: Isoprenaline-induced acute myocardial infarction (150 mg/kg subcutaneously on two consecutive days, 24 h apart)

Cardiac injury markers rose after isoprenaline in both infarcted groups but were significantly lower in the trained plus infarcted group than in the infarcted group. Training alone raised cardiac G-CSF and C-kit relative to control, and the rise in G-CSF, G-CSFR and C-kit after infarction was blunt…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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